Chemical Proteomics & Covalent Ligand Discovery
We design stereochemically defined electrophiles and activity-based protein profiling workflows to map ligandable sites and discover chemical probes in native biological systems.
Functional Genomics & Mechanism of Action
We use CRISPR screening and focused genetic perturbations to identify drug targets, resistance pathways, and synthetic-lethal dependencies.
Protein Modulation & Disease Biology
We define how covalent ligands alter protein activity, stability, complexes, and signaling to create new therapeutic opportunities.
A continuous loop from chemistry to function
- Design molecules: create structurally and stereochemically diverse probes.
- Measure engagement: quantify proteome-wide, site-resolved interactions.
- Define mechanism: connect engagement to protein-state changes and cellular phenotypes.
- Discover vulnerabilities: use genetic perturbation and disease models to identify therapeutic opportunities.