Publications

2025

2025

An Allosteric Cyclin E–CDK2 Site Mapped by Paralog Hopping with Covalent Probes

Zhang, Y.; Liu, Z.; Hirschi, M.; Brodsky, O.; Johnson, E.; Won, S. J.; Nagata, A.; Petroski, M. D.; Majmudar, J. D.; Niessen, S.; VanArsdale, T.; Gilbert, A. M.; Hayward, M. M.; Stewart, A. E.; Nager, A. R.; Melillo, B.; Cravatt, B. F.

Nature Chemical Biology, 21, 420–431

DOI PubMed Details

2024

2024

Coordinated Inheritance of Extrachromosomal DNAs in Cancer Cells

Hung, K. L.; Jones, M. G.; Wong, I. T. L.; Curtis, E. J.; Lange, J. T.; He, B. J.; Luebeck, J.; Schmargon, R.; Scanu, E.; Brückner, L.; Yan, X.; Li, R.; Gnanasekar, A.; González, R. C.; Belk, J. A.; Liu, Z.; Melillo, B.; Bafna, V.; Dörr, J. R.; Werner, B.; Huang, W.; Cravatt, B. F.; Henssen, A. G.; Mischel, P. S.; Chang, H. Y.

Nature, 635, 201–209

DOI PubMed Details

2024

Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders

Liu, Z.; Remsberg, J. R.; Li, H.; Njomen, E.; DeMeester, K. E.; Tao, Y.; Xia, G.; Yoo, M.; Nguyen, T.; Simon, G. M.; Schreiber, S. L.; Melillo, B.; Cravatt, B. F.

Journal of the American Chemical Society, 146, 10393–10406

DOI PubMed Details

2023

2023

A Sterically Tuned Directing Auxiliary Promotes Catalytic 1,2-Carbofluorination of Alkenyl Carbonyl Compounds

Liu, Z.; Oxtoby, L. J.; Sun, J.; Li, Z.-Q.; Kim, N.; Davies, G. H. M.; Engle, K. M.

Angewandte Chemie International Edition, 62, e202214153

DOI Details

2021

2021

A Transient Directing Group Strategy Enables Enantioselective Multicomponent Organofluorine Synthesis

Liu, Z.; Oxtoby, L. J.; Liu, M.; Li, Z.-Q.; Tran, V. T.; Gao, Y.; Engle, K. M.

Journal of the American Chemical Society, 143, 8962–8969

DOI PubMed Details

2020

2020

Controlling Cyclization Pathways in Palladium(II)-Catalyzed Intramolecular Alkene Hydrofunctionalization via Substrate Directivity

Wang, X.; Li, Z.-Q.; Mai, B. K.; Gurak, J. A.; Xu, J. E.; Tran, V. T.; Ni, H.-Q.; Liu, Z.; Liu, Z.; Yang, K. S.; Xiang, R.; Liu, P.; Engle, K. M.

Chemical Science, 11, 11307–11314

Details

2019

2019

Copper-Catalyzed Late-Stage Benzylic C(sp3)–H Trifluoromethylation

Xiao, H.; Liu, Z.; Shen, H.; Zhang, B.; Zhu, L.; Li, C.

Chem, 5, 940–949

Details

2019

Copper-Catalyzed Remote C(sp3)–H Trifluoromethylation of Carboxamides and Sulfonamides

Liu, Z.; Xiao, H.; Zhang, B.; Shen, H.; Zhu, L.; Li, C.

Angewandte Chemie International Edition, 58, 2510–2513

Details

2019

Copper-Catalyzed Ring-Opening Radical Trifluoromethylation of Cycloalkanone Oximes

Liu, Z.; Shen, H.; Xiao, H.; Wang, Z.; Zhu, L.; Li, C.

Organic Letters, 21, 5201–5206

Details

2018

2018

Radical Carbofluorination of Unactivated Alkenes with Fluoride Ions

Liu, Z.; Chen, H.; Lv, Y.; Tan, X.; Shen, H.; Yu, H.-Z.; Li, C.

Journal of the American Chemical Society, 140, 6169–6175

DOI PubMed Details

2017

2017

Catalytic Radical Trifluoromethylalkynylation of Unactivated Alkenes

Zhou, S.; Song, T.; Chen, H.; Liu, Z.; Shen, H.; Li, C.

Organic Letters, 19, 698–701

Details

2017

Selective Radical Fluorination of Tertiary Alkyl Halides at Room Temperature

Chen, H.; Liu, Z.; Lv, Y.; Tan, X.; Shen, H.; Yu, H.-Z.; Li, C.

Angewandte Chemie International Edition, 56, 15411–15415

Details

2017

Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Tan, X.; Liu, Z.; Shen, H.; Zhang, P.; Zhang, Z.; Li, C.

Journal of the American Chemical Society, 139, 12430–12433

Details

2017

Trifluoromethylation of Alkyl Radicals in Aqueous Solution

Shen, H.; Liu, Z.; Zhang, P.; Tan, X.; Zhang, Z.; Li, C.

Journal of the American Chemical Society, 139, 9843–9846

Details